The microscopic pattern of liver biopsies for non-neoplastic diseases has changed with increasing emphasis on steatohepatitis, fibrosis regression and drug-induced liver disease. The reasons for these changes (based on consultative cases at several large medical centers) include classification of an hepatic pattern of injury, primary biliary cholangitis, fatty liver disease, autoimmune hepatitis, etiology of cirrhosis and transplant pathology (unpublished data). Among the neoplastic cases, hepatocellular carcinoma, cholangiocarcinoma/metastatic adenocarcinoma and hepatocellular adenoma are the leading areas that cause problems in diagnosis for practicing pathologists. Advances in radiologic techniques facilitate targeting smaller lesions, necessitating judicious use of immunohistochemistry. In the last few years, characteristic molecular changes have been described in a variety of liver tumors and are increasingly being used for diagnosis. Take advantage of this fantastic mentoring opportunity to study liver interactively with experts who can improve your performance and enhance your practice.